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M5 Pro and M5 Max are built using the new Apple-designed Fusion Architecture and engineered from the ground up for AI. This innovative design combines two dies into a single system on a chip, providing tremendous performance boosts. M5 Pro and M5 Max feature a new up-to-18-core CPU with 6 super cores, the world’s fastest CPU core,1 and 12 all-new performance cores, optimized for power-efficient, multithreaded pro workloads — altogether delivering up to 30 percent faster performance.3 M5 Pro is designed for users running complex workflows, like coders optimizing algorithms and photographers processing massive image libraries, while M5 Max is for those pushing the absolute limits, such as engineers running rigorous simulations.

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then the += will modify the list, and then raise an exception because you can’t assign to that tuple item because the tuple is immutable, but the list will have been mutated.

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PacBio’s ability to produce extremely long reads makes it a useful complement to Illumina. Indeed, PacBio machines are better at sequencing “confusing” genomes, such as those with many copies of the same gene, long stretches of repetitive motifs, and “structural variations” like large insertions or deletions, which may not show up in short-read sequences. For instance, PacBio was used to sequence a very difficult bacterium called Clostridium autoethanogenum, which contains repeats, nine copies of a single gene, and insertions from bacterial virus genomes — basically the genomic equivalent of a Thomas Pynchon novel.